Structure of PDB 4qpl Chain A

Receptor sequence
>4qplA (length=153) Species: 10090 (Mus musculus) [Search protein sequence]
SLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPE
DFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFS
KGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAG
LRL
3D structure
PDB4qpl Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V3L A K61 Y107 G109 R110 W114 Y116 I139 Y144 Q153 R161 R163 K175 G179 K32 Y78 G80 R81 W85 Y87 I110 Y115 Q124 R132 R134 K146 G150 MOAD: Kd=39nM
PDBbind-CN: -logKd/Ki=7.41,Kd=39nM
BS02 ZN A C36 C39 C56 C59 C7 C10 C27 C30
BS03 ZN A C51 H53 C70 C73 C22 H24 C41 C44
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0072572 poly-ADP-D-ribose binding
Biological Process
GO:0016055 Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4qpl, PDBe:4qpl, PDBj:4qpl
PDBsum4qpl
PubMed25327252
UniProtQ9CZW6|RN146_MOUSE E3 ubiquitin-protein ligase RNF146 (Gene Name=Rnf146)

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