Structure of PDB 4qox Chain A

Receptor sequence
>4qoxA (length=462) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
SKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKV
ISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVY
TGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENIL
LETKNEDMIIKIIDFGLSTHFEYSKIGTAYYIAPDVLHGTYDEKCDIWSC
GVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIK
KMLMYTSAVRISARDALEHEWIKMMTSKLELSIANIRQFQSTQKLAQAAL
LYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGET
SDLDNAAIEYEVDQILNSIDLDQNGYIEYSEFLTVSIDRKLLLSTERLEK
AFKLFDKDGSGKISANELAQLFGLSDVSSECWKTVLKEVDQNNDGEIDFK
EFRDMLVKLCNY
3D structure
PDB4qox Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500
ChainA
Resolution2.748 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D193 K195 E197 N198 D215 T234
Catalytic site (residue number reindexed from 1) D143 K145 E147 N148 D164 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D389 N391 D393 Q395 D324 N326 D328 Q330
BS02 DXR A L76 G77 K78 V84 A97 K99 M131 L145 D148 Y150 L200 L26 G27 K28 V34 A47 K49 M81 L95 D98 Y100 L150
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0030154 cell differentiation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qox, PDBe:4qox, PDBj:4qox
PDBsum4qox
PubMed
UniProtQ8IBS5|CDPK4_PLAF7 Calcium-dependent protein kinase 4 (Gene Name=CDPK4)

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