Structure of PDB 4qo9 Chain A

Receptor sequence
>4qo9A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
ADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI
QQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLD
ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAG
QLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEP
PHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKE
LLKHKFILRNAKKTSYLTELIDRYKRWKAEQ
3D structure
PDB4qo9 Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 D171 T182
Catalytic site (residue number reindexed from 1) D127 K129 A131 N132 D145 D154 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 627 A I30 A51 K53 M99 E100 Y101 L102 G103 G104 L151 Y291 I13 A34 K36 M82 E83 Y84 L85 G86 G87 L134 Y274 MOAD: ic50=0.16uM
PDBbind-CN: -logKd/Ki=6.80,IC50=0.16uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4qo9, PDBe:4qo9, PDBj:4qo9
PDBsum4qo9
PubMed27135311
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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