Structure of PDB 4qo4 Chain A

Receptor sequence
>4qo4A (length=89) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4qo4 Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 35S A L54 F55 G58 I61 M62 F86 V93 K94 H96 I99 Y100 L37 F38 G41 I44 M45 F65 V72 K73 H75 I78 Y79 MOAD: ic50=0.005uM
PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qo4, PDBe:4qo4, PDBj:4qo4
PDBsum4qo4
PubMed25147610
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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