Structure of PDB 4qn5 Chain A

Receptor sequence

>4qn5A (length=394) Species: 352705 (Influenza A virus (A/mallard duck/ALB/60/1976(H12N5)))

PEFLNNTEPLCNVSGFAIVSKDNGIRIGSRGHVFVIREPFVACGPTECRT
FFLTQGALLNDKHSNNTVKDRSPYRALMSVPLGSSPNAYQAKFESVAWSA
TACHDGKKWLAVGISGADDDAYAVIHYGGMPTDVVRSWRKQILRTQESSC
VCMNGNCYWVMTDGPANSQASYKIFKSHEGMVTNEREVSFQGGHIEECSC
YPNLGKVECVCRDNWNGMNRPILIFDEDLDYEVGYLCAGIPTDTPRVQDS
SFTGSCTNAVGGSGTNNYGVKGFGFRQGNSVWAGRTVSISSRSGFEILLI
EDGWIRTSKTIVKKVEVLNNKNWSGYSGAFTIPITMTSKQCLVPCFWLEM
IRGKPEERTSIWTSSSSTVFCGVSSEVPGWSWDDGAILPFDIDK

3D structure

• PDB: 4qn5 Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D70 E197 R212 R292 Y326
• Catalytic site (residue number reindexed from 1): D70 E197 R212 R292 Y326
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SIA	A	S288 S291 S293 N320 K321 N322 W323	S288 S291 S293 N320 K321 N322 W323
BS02	CA	A	D213 G217 D243 Y268	D213 G217 D243 Y268
BS03	SIA	A	E38 D70 W98 A166 E196 R212 R292 Y326	E38 D70 W98 A166 E196 R212 R292 Y326

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:4qn5, PDBe:4qn5, PDBj:4qn5
• PDBsum: 4qn5
• PubMed: 24899180
• UniProt: Q20UH7