Structure of PDB 4qmx Chain A

Receptor sequence
>4qmxA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE
DEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL
EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLA
DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIE
LARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSF
RPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQS
3D structure
PDB4qmx Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).
ChainA
Resolution1.882 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 D171 T182
Catalytic site (residue number reindexed from 1) D133 K135 A137 N138 D151 D160 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H8H A I30 K32 A51 K53 M99 Y101 L102 I19 K21 A40 K42 M88 Y90 L91 MOAD: ic50=11uM
PDBbind-CN: -logKd/Ki=4.96,IC50=11uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4qmx, PDBe:4qmx, PDBj:4qmx
PDBsum4qmx
PubMed27135311
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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