Structure of PDB 4qmv Chain A

Receptor sequence
>4qmvA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE
AEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALD
LLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVK
LADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITA
IELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEP
SFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ
3D structure
PDB4qmv Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 D171 T182
Catalytic site (residue number reindexed from 1) D135 K137 A139 N140 D153 D162 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 34W A E28 I30 V38 E100 L102 G105 L151 Y291 E19 I21 V29 E91 L93 G96 L142 Y282 MOAD: ic50=0.023uM
PDBbind-CN: -logKd/Ki=7.64,IC50=0.023uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4qmv, PDBe:4qmv, PDBj:4qmv
PDBsum4qmv
PubMed27135311
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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