Structure of PDB 4qms Chain A

Receptor sequence
>4qmsA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI
EDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPG
PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFG
VAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAR
GEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPT
AKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ
3D structure
PDB4qms Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).
ChainA
Resolution1.883 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 D171 T182
Catalytic site (residue number reindexed from 1) D130 K132 A134 N135 D148 D157 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A A51 K53 M99 Y101 L102 G103 L151 D162 A37 K39 M85 Y87 L88 G89 L137 D148 MOAD: ic50=7.4uM
PDBbind-CN: -logKd/Ki=5.13,IC50=7.4uM
BindingDB: Kd=>10000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4qms, PDBe:4qms, PDBj:4qms
PDBsum4qms
PubMed27135311
UniProtQ9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (Gene Name=STK24)

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