Structure of PDB 4ql8 Chain A

Receptor sequence
>4ql8A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACCSRRFYQLTKLLDSVQPIARELHQFT
FDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB4ql8 3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JAD A L704 N705 L707 W741 M742 M745 M749 F764 M780 F876 T877 L34 N35 L37 W71 M72 M75 M79 F94 M110 F199 T200 MOAD: ic50=0.7nM
PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
BindingDB: EC50=0.500000nM,IC50=0.700000nM
External links
PDB RCSB:4ql8, PDBe:4ql8, PDBj:4ql8
PDBsum4ql8
PubMed25121964
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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