Structure of PDB 4qk4 Chain A

Receptor sequence
>4qk4A (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SGGPNVPELILQLLQLEPDEDQVRARILGSLQEPTKSRPDQPAAFGLLCR
MADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQH
GKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQE
FVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHSGDKFQ
QLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
3D structure
PDB4qk4 The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R281 M295 E454 M455 R64 M78 E237 M238
BS02 PIK A F262 L265 C266 S303 L306 V307 L344 L429 A433 Y436 L437 H439 F45 L48 C49 S86 L89 V90 L127 L212 A216 Y219 L220 H222 PDBbind-CN: -logKd/Ki=6.60,Kd=250nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:4qk4, PDBe:4qk4, PDBj:4qk4
PDBsum4qk4
PubMed25288771
UniProtQ13285|STF1_HUMAN Steroidogenic factor 1 (Gene Name=NR5A1)

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