Structure of PDB 4qjr Chain A

Receptor sequence
>4qjrA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SGGPNVPELILQLLQLEPDEDQVRARILGSLQEPTKSRPDQPAAFGLLCR
MADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQH
GKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQE
FVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHSGDKFQ
QLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
3D structure
PDB4qjr The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I274 V277 R281 M295 E454 M455 I57 V60 R64 M78 E237 M238
BS02 PIZ A L265 L306 Q339 A340 G341 L344 L429 Y436 K440 L48 L89 Q122 A123 G124 L127 L212 Y219 K223 MOAD: Kd=80nM
PDBbind-CN: -logKd/Ki=7.10,Kd=80nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:4qjr, PDBe:4qjr, PDBj:4qjr
PDBsum4qjr
PubMed25288771
UniProtQ13285|STF1_HUMAN Steroidogenic factor 1 (Gene Name=NR5A1)

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