Structure of PDB 4qin Chain A

Receptor sequence
>4qinA (length=447) Species: 562,9606 [Search protein sequence]
QCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVT
GLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARR
EIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHT
SFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICF
VGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADLEDNWE
TLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEM
KDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLAA
SKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQA
NDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR
3D structure
PDB4qin Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SG8 A N219 L221 M301 L303 D384 Y394 K395 H470 D473 W480 E481 F484 P513 E518 N28 L30 M110 L112 D193 Y203 K204 H378 D381 W388 E389 F392 P409 E414
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4qin, PDBe:4qin, PDBj:4qin
PDBsum4qin
PubMed25008467
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q99835|SMO_HUMAN Protein smoothened (Gene Name=SMO)

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