Structure of PDB 4qim Chain A

Receptor sequence
>4qimA (length=457) Species: 562,9606 [Search protein sequence]
SGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGA
VTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGA
RREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAW
HTSFKALLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYK
NYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADLEDNWETLND
NLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFR
HGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLAASKIN
ETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTI
GLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWR
RTWCRLT
3D structure
PDB4qim Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
ChainA
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A8T A N219 L221 W281 D384 V386 S387 F391 Y394 K395 R400 H470 D473 Q477 E518 N521 N30 L32 W92 D189 V191 S192 F196 Y199 K200 R205 H374 D377 Q381 E422 N425
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:4qim, PDBe:4qim, PDBj:4qim
PDBsum4qim
PubMed25008467
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q99835|SMO_HUMAN Protein smoothened (Gene Name=SMO)

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