Structure of PDB 4qik Chain A

Receptor sequence
>4qikA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
GVEDTKHYEEAKKCVEELALYLKPLSSARGVGLNSTTQSVLSRPMQRKLV
TLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVR
ARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQAS
KTSIGHVVQLLYRASCFKSLMQLKEEFRTYEALRREHDSQIVQIAMEAGL
RIAPDQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGD
PANLNRLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQ
NH
3D structure
PDB4qik The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S315 Q318 S319 D322 K323 S219 Q222 S223 D226 K227
BS02 rna A R131 R135 R164 R43 R47 R76
External links
PDB RCSB:4qik, PDBe:4qik, PDBj:4qik
PDBsum4qik
PubMed25026078
UniProtQ5TC82|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)

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