Structure of PDB 4qii Chain A

Receptor sequence
>4qiiA (length=300) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
LSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPH
TVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSG
YQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHS
LHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFF
LGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFA
FNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF
3D structure
PDB4qii Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
ChainA
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G91 R96 Y101 R116 H121 G147 S150 D171 S176 D178 G179 A265 Y273
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NE A V57 R58 A60 F61 S103 G104 G105 D106 Q107 I136 W157 G160 G161 T184 D185 V188 S190 V43 R44 A46 F47 S89 G90 G91 D92 Q93 I122 W143 G146 G147 T170 D171 V174 S176
BS02 2NE A Y287 F299 K302 Y273 F285 K288
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:4qii, PDBe:4qii, PDBj:4qii
PDBsum4qii
PubMed25372686
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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