Structure of PDB 4qi2 Chain A

Receptor sequence
>4qi2A (length=153) Species: 10090 (Mus musculus) [Search protein sequence]
HQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVL
VLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEE
FRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIID
KLQ
3D structure
PDB4qi2 Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R188 R219 K220 S238 K239 T240 Q247 Y250 R251 E262 D263 S264 S265 R16 R47 K48 S66 K67 T68 Q75 Y78 R79 E90 D91 S92 S93 PDBbind-CN: Kd=119nM
External links
PDB RCSB:4qi2, PDBe:4qi2, PDBj:4qi2
PDBsum4qi2
PubMed25026077
UniProtQ4VGL6|RC3H1_MOUSE Roquin-1 (Gene Name=Rc3h1)

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