Structure of PDB 4qh9 Chain A

Receptor sequence
>4qh9A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEE
APDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQ
APLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQR
WDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQER
QGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLL
SHSLLPALCDSKIRSKALGSDHCPITLYLAL
3D structure
PDB4qh9 High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
ChainA
Resolution2.175 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N68 D70 E96 Y171 D210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N31 D33 E59 Y134 D173 N175 D246 D271 H272
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D70 E96 D33 E59
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4qh9, PDBe:4qh9, PDBj:4qh9
PDBsum4qh9
PubMed25251148
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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