Structure of PDB 4qh3 Chain A

Receptor sequence
>4qh3A (length=117) Species: 9913 (Bos taurus) [Search protein sequence]
KETAAAKFERQHMDSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAV
CSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHII
VACEGNPYVPVHFDASV
3D structure
PDB4qh3 Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II).
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H12 K34 H112 F113 D114
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I83 A T78 H105 T71 H98
BS02 I83 A H48 Q101 H41 Q94
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qh3, PDBe:4qh3, PDBj:4qh3
PDBsum4qh3
PubMed25025479
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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