Structure of PDB 4qgn Chain A

Receptor sequence
>4qgnA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDP
ELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILD
GSGYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFV
GEPVWTAYNRPADHFEARGQYVKFLAQT
3D structure
PDB4qgn On the Structure and Reaction Mechanism of Human Acireductone Dioxygenase.
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.53: acireductone dioxygenase (Ni(2+)-requiring).
1.13.11.54: acireductone dioxygenase (Fe(2+)-requiring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H88 H90 E94 H133 H88 H90 E94 H133
BS02 MSE A F84 H88 H90 E94 H133 F84 H88 H90 E94 H133
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity
GO:0016151 nickel cation binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qgn, PDBe:4qgn, PDBj:4qgn
PDBsum4qgn
PubMed29193386
UniProtQ9BV57|MTND_HUMAN Acireductone dioxygenase (Gene Name=ADI1)

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