Structure of PDB 4qg0 Chain A

Receptor sequence

>4qg0A (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4qg0 Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	A	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337
BS02	DUT	A	L150 R164 R206 H210 H215 D311 K312 Y315 D319 R366 Y374	L38 R52 R94 H98 H103 D193 K194 Y197 D201 R248 Y256
BS03	DUT	A	R333 R352 K354 K523	R215 R234 K236 K405
BS04	DUT	A	V117 N119	V5 N7
BS05	DUT	A	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS06	DGT	A	K116 D137 R145	K4 D25 R33

External links

PDB	RCSB:4qg0, PDBe:4qg0, PDBj:4qg0
PDBsum	4qg0
PubMed	25288794
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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