Structure of PDB 4qfx Chain A

Receptor sequence

>4qfxA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4qfx Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	A	Y155 V156 R451 K455	Y43 V44 R333 K337
BS02	DGT	A	Q149 L150 R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374 Q375	Q37 L38 R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256 Q257
BS03	DTP	A	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS04	DGT	A	K116 V117 I118 D137 Q142 R145	K4 V5 I6 D25 Q30 R33
BS05	MG	A	R206 D309	R94 D191
BS06	DTP	A	V117 N119	V5 N7
BS07	DTP	A	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259

External links

PDB	RCSB:4qfx, PDBe:4qfx, PDBj:4qfx
PDBsum	4qfx
PubMed	25288794
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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