Structure of PDB 4qf5 Chain A

Receptor sequence
>4qf5A (length=459) Species: 557600 (Acinetobacter baumannii AB307-0294) [Search protein sequence]
STVPLEPWTAQQLQQATQGYWHKDQIPQTEIKRILTDSRHAESGDAFLAL
KGERFDAHNFVAQVVANGCQVAIVERPIDAEIAQLVVADTRLALGQLGAY
RREQNAQLKVIALTGSSGKTTTKEMLGSILSRLAPTLITRGNLNNDLGVP
MMLLELRKEHQYAVMELGANHQGEIDYTSKIVQPHVAGILNIGTAHLGEF
GGRDGICRAKSEIYRHILPQGVAIVPQQDDFTAEIREAAKSHQIMSFGEG
GDVFATEIELLPQSANFQLHTPQGSSFVRLPFAGEHNVQNATAAVAFALA
LGVSLEDIVKGLEQAQGAKGRLNFIQKAPHLFIDDTYNANPTSMRAAAQV
LLQQNGIKVMVMGDIGELGDSSWQEHHDLGRDLAELPLDHIVAVGQFASA
ALEGAGLHSTKLKAFQTQAEALPFLINLIQTHQPQSMSFLFKGSRFTHME
TLMADLMEK
3D structure
PDB4qf5 ATP-binding mode including a carbamoylated lysine and two Mg(2+) ions, and substrate-binding mode in Acinetobacter baumannii MurF
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K125 T126 N148 E172 H202
Catalytic site (residue number reindexed from 1) K119 T120 N142 E166 H196
Enzyme Commision number 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S123 G124 K125 T126 T127 E172 H292 R327 D341 N344 S349 S117 G118 K119 T120 T121 E166 H286 R321 D335 N338 S343
BS02 MG A T126 E172 T120 E166
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0046872 metal ion binding
GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qf5, PDBe:4qf5, PDBj:4qf5
PDBsum4qf5
PubMed24978312
UniProtA0A0J9X1Z8

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