Structure of PDB 4qev Chain A

Receptor sequence
>4qevA (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
LSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGAHDYHDIIKHPMD
LSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
FEFRYAKMPD
3D structure
PDB4qev Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 31O A W370 P371 F372 Y428 N429 V435 W25 P26 F27 Y83 N84 V90 PDBbind-CN: -logKd/Ki=7.66,Kd=22nM
BindingDB: Kd=1470nM
External links
PDB RCSB:4qev, PDBe:4qev, PDBj:4qev
PDBsum4qev
PubMed25323695
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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