Structure of PDB 4qep Chain A

Receptor sequence

>4qepA (length=467) Species: 3702 (Arabidopsis thaliana)

LEPHLKVTKCLRLFNKQYLLCVQAKLSRPDLKGVTEMIKAKAILYPRKII
GDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYEKEYSNYKLPLA
VSIVMSGQYEDDLDNADTVTYTGQGGHNLTGNKRQIKDQLLERGNLALKH
CCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKY
RLKRLEGQPELTTDEGLVCEDISGGLEFKGIPATNRVDDSPVSPTSGFTY
IKSLIIEPNVIIPKSSTGCNCRGSCTDSKKCACAKLNGGNFPYVDLNDGR
LIESRDVVFECGPHCGCGPKCVNRTSQKRLRFNLEVFRSAKKGWAVRSWE
YIPAGSPVCEYIGVVRRTADVNEYIFEIDCPEFCIDAGSTGNFARFINHS
CEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALDSVHKV
KQLACYCGALNCRKRLY

3D structure

• PDB: 4qep Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y475 Y593
• Catalytic site (residue number reindexed from 1): Y361 Y440
• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R126 R163 W175 L176 N177 G178 S204 Q206 Y207 D210 Y219 T220 G223 L227 R241 K270 Y273	R28 R65 W77 L78 N79 G80 S106 Q108 Y109 D112 Y121 T122 G125 L129 R143 K172 Y175
BS02	dna	A	K130 T133 I136 H174 W175 S183	K32 T35 I38 H76 W77 S85
BS03	SAH	A	W458 R548 N551 H552 Y593 C612	W344 R395 N398 H399 Y440 C455
BS04	ZN	A	C383 C397 C425 C429	C269 C283 C311 C315
BS05	ZN	A	C425 C431 C435	C311 C317 C321
BS06	ZN	A	C383 C389	C269 C275
BS07	ZN	A	C612 C614 C619	C455 C457 C462

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4qep, PDBe:4qep, PDBj:4qep
• PDBsum: 4qep
• PubMed: 25018018
• UniProt: Q8GZB6|SUVH4_ARATH Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (Gene Name=SUVH4)