Structure of PDB 4qek Chain A

Receptor sequence
>4qekA (length=281) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDI
NTPAFEEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTR
EMPAWLQANKGVSPTGNAAVGLAMSGGSALILAAYYPQQFPYAASLSGFL
NPSEGWWPTLIGLAMNDSGGYNANSMWGPSSDPAWKRNDPMVQIPRLVAN
NTRIWVYCGNGTPSDLGGDNIPAKFLEGLTLRTNQTFRDTYAADGGRNGV
FNFPPNGTHSWPYWNEQLVAMKADIQHVLNG
3D structure
PDB4qek Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors.
ChainA
Resolution1.299 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.122: trehalose O-mycolyltransferase.
2.3.1.20: diacylglycerol O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A T100 P104 A105 P115 Q140 T99 P103 A104 P114 Q139
Gene Ontology
Molecular Function
GO:0004144 diacylglycerol O-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0035375 zymogen binding
GO:0050348 trehalose O-mycolyltransferase activity
Biological Process
GO:0006869 lipid transport
GO:0009247 glycolipid biosynthetic process
GO:0046677 response to antibiotic
GO:0071769 mycolate cell wall layer assembly
Cellular Component
GO:0005576 extracellular region
GO:0009274 peptidoglycan-based cell wall

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Cellular Component
External links
PDB RCSB:4qek, PDBe:4qek, PDBj:4qek
PDBsum4qek
PubMed25028518
UniProtP9WQN9|A85C_MYCTU Diacylglycerol acyltransferase/mycolyltransferase Ag85C (Gene Name=fbpC)

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