Structure of PDB 4qde Chain A

Receptor sequence
>4qdeA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
VRLPFSGFRLQKVLRESARDKIIFLHGKVEDAVVILEKTPFQVEQVAQLL
TGSPELQLQFSNIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLR
LIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDG
FVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQ
EAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLA
EVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ
3D structure
PDB4qde Dcps in complex with covalent inhibitors
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 30S A K142 W175 E185 D205 L206 Y273 K93 W126 E136 D156 L157 Y224
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0004532 RNA exonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:0110156 mRNA methylguanosine-cap decapping
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qde, PDBe:4qde, PDBj:4qde
PDBsum4qde
PubMed
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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