Structure of PDB 4qbq Chain A

Receptor sequence
>4qbqA (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLE
CAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ
AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFA
3D structure
PDB4qbq Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs
ChainA
Resolution2.406 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A C549 C554 C583 C586 C76 C81 C110 C113
BS02 ZN A C537 C540 C559 C562 C64 C67 C86 C89
BS03 ZN A C494 C497 C514 C517 C21 C24 C41 C44
External links
PDB RCSB:4qbq, PDBe:4qbq, PDBj:4qbq
PDBsum4qbq
PubMed
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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