Structure of PDB 4qb8 Chain A

Receptor sequence
>4qb8A (length=267) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFAAPL
VAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIR
YSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPP
GDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAG
FPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEP
REALLAEAATCVAGVLA
3D structure
PDB4qb8 Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the beta-lactamase from Mycobacterium tuberculosis.
ChainA
Resolution1.758 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S84 A87 S142 E182 K250 T253
Catalytic site (residue number reindexed from 1) S44 A47 S102 E142 K210 T213
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1TE A S84 I117 S142 E182 T251 G252 T253 S44 I77 S102 E142 T211 G212 T213
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qb8, PDBe:4qb8, PDBj:4qb8
PDBsum4qb8
PubMed24846409
UniProtP9WKD3|BLAC_MYCTU Beta-lactamase (Gene Name=blaC)

[Back to BioLiP]