Structure of PDB 4qb3 Chain A

Receptor sequence
>4qb3A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4qb3 Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
ChainA
Resolution0.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 30M A W81 F83 L94 N140 D144 D145 I146 W40 F42 L53 N99 D103 D104 I105 MOAD: Kd=3.4uM
PDBbind-CN: -logKd/Ki=5.47,Kd=3.4uM
BindingDB: Kd=3400nM,Ki=17200nM
External links
PDB RCSB:4qb3, PDBe:4qb3, PDBj:4qb3
PDBsum4qb3
PubMed24954007
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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