Structure of PDB 4qag Chain A

Receptor sequence
>4qagA (length=133) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
LWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTN
QKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQ
LIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR
3D structure
PDB4qag Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs.
ChainA
Resolution1.712 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D443 D549 D19 D125
BS02 MN A D443 E478 D498 D19 E54 D74
BS03 F95 A D443 E478 D498 S499 H539 D19 E54 D74 S75 H115 MOAD: ic50=4.8uM
PDBbind-CN: -logKd/Ki=5.32,IC50=4.8uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4qag, PDBe:4qag, PDBj:4qag
PDBsum4qag
PubMed24840303
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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