Structure of PDB 4qab Chain A

Receptor sequence
>4qabA (length=208) Species: 6523 (Lymnaea stagnalis) [Search protein sequence]
DYKDDDDKLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVN
EITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAI
SKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGS
WTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEV
SLNFRKKG
3D structure
PDB4qab Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
ChainA
Resolution2.984 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KK2 A Y89 W143 Y185 C188 Y192 Y97 W151 Y188 C191 Y195 PDBbind-CN: -logKd/Ki=9.70,Kd=0.2nM
BS02 KK2 A W53 M114 Y164 W61 M122 Y167 PDBbind-CN: -logKd/Ki=9.70,Kd=0.2nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050877 nervous system process
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043083 synaptic cleft
GO:0045202 synapse
GO:0098794 postsynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qab, PDBe:4qab, PDBj:4qab
PDBsum4qab
PubMed25006260
UniProtP58154|ACHP_LYMST Acetylcholine-binding protein

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