Structure of PDB 4q93 Chain A

Receptor sequence
>4q93A (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF
VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA
MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV
KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG
YSKRVHLMNPMVPGLTGSKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLS
FIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNS
VEVALNKLLDPIREKFNTPALKKLASAAYP
3D structure
PDB4q93 A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STL A Y39 G41 L72 H77 Y166 Q170 D173 Y36 G38 L69 H74 Y163 Q167 D170 PDBbind-CN: -logKd/Ki=4.65,Ki=22.3uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4q93, PDBe:4q93, PDBj:4q93
PDBsum4q93
PubMed25533949
UniProtP54577|SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (Gene Name=YARS1)

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