Structure of PDB 4q8f Chain A

Receptor sequence

>4q8fA (length=425) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKLSSLRRCCALTRYDAHKMSHDAFTVIKNCN
TSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4q8f Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage.
• Chain: A
• Resolution: 2.797 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 W64 K86 K293 P316 K317 G320 C321 S322 K323 N324 P326 R351	Q38 Y39 W42 W64 K86 K288 P311 K312 G315 C316 S317 K318 N319 P321 R345
BS02	dna	A	S113 E116 K224 R256 S257 G259 G260 K261 L262 R382 C384	S113 E116 K219 R251 S252 G254 G255 K256 L257 R375 C377
BS03	MG	A	D13 M14 D115	D13 M14 D115
BS04	MG	A	D13 D115 E116	D13 D115 E116
BS05	XG4	A	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K226
BS06	XG4	A	S257 K293 N294 W297	S252 K288 N289 W292

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4q8f, PDBe:4q8f, PDBj:4q8f
• PDBsum: 4q8f
• PubMed: 24927576
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)