Structure of PDB 4q80 Chain A

Receptor sequence
>4q80A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRT
GLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAV
LGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVL
DPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVS
FSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSS
3D structure
PDB4q80 Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease.
ChainA
Resolution3.07 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 S192 A193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D89 S182 A183 D184 S185 G186
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2YS A H57 H99 S195 F215 S216 G217 H41 H86 S185 F201 S202 G203
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008201 heparin binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0035578 azurophil granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4q80, PDBe:4q80, PDBj:4q80
PDBsum4q80
PubMed25156428
UniProtQ6UWY2|PRS57_HUMAN Serine protease 57 (Gene Name=PRSS57)

[Back to BioLiP]