Structure of PDB 4q5m Chain A

Receptor sequence
>4q5mA (length=198) Species: 11706 (HIV-1 M:B_HXB2R) [Search protein sequence]
PQVTLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QVTLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIG
GFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
3D structure
PDB4q5m Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir.
ChainA
Resolution1.795 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1025 T1026 G1027
Catalytic site (residue number reindexed from 1) D124 T125 G126
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ROC A R8 D25 G27 N30 G49 I84 D1025 G1027 D1029 N1030 G1048 I1050 P1081 I1084 R8 D25 G27 N30 G49 I84 D124 G126 D128 N129 G147 I149 P180 I183
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4q5m, PDBe:4q5m, PDBj:4q5m
PDBsum4q5m
PubMed25487655
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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