Structure of PDB 4q4c Chain A

Receptor sequence

>4q4cA (length=325) Species: 9606 (Homo sapiens)

RQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENW
PLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSIL
QAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSA
EDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMP
TDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREK
LIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKI
LGNIVMRELAPQFHIPWSIPLEAED

3D structure

• PDB: 4q4c Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	R134 V185 K187 H194 L211 E237 F239 M240 D246 L311 D321	R93 V144 K146 H153 L170 E196 F198 M199 D205 L270 D280
BS02	I8P	A	K53 K54 R213 K214 K248 R273 R281 D321 N323 S326 K329	K12 K13 R172 K173 K207 R232 R240 D280 N282 S285 K288
BS03	MG	A	D321 N323	D280 N282
BS04	MG	A	D309 D321	D268 D280
BS05	MG	A	S68 F70 I73	S27 F29 I32

Gene Ontology

Molecular Function

• GO:0000829 diphosphoinositol pentakisphosphate kinase activity

External links

• PDB: RCSB:4q4c, PDBe:4q4c, PDBj:4q4c
• PDBsum: 4q4c
• PubMed: 25044992
• UniProt: O43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)