Structure of PDB 4pzz Chain A

Receptor sequence
>4pzzA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDCYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB4pzz A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
ChainA
Resolution1.403 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 S146 A147
BS02 2XO A K5 V7 C39 D54 K6 V8 C40 D55
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4pzz, PDBe:4pzz, PDBj:4pzz
PDBsum4pzz
PubMed25087006
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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