Structure of PDB 4pzi Chain A

Receptor sequence
>4pziA (length=61) Species: 9606 (Homo sapiens) [Search protein sequence]
HHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKC
DKIEARKMERL
3D structure
PDB4pzi DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K960 M961 R962 T995 K996 K997 Q998 K5 M6 R7 T40 K41 K42 Q43
BS02 dna A R962 M963 R965 K997 Q998 C999 R7 M8 R10 K42 Q43 C44
BS03 ZN A C966 C969 C972 C1005 C11 C14 C17 C50
BS04 ZN A C978 C981 C984 C1000 C23 C26 C29 C45
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4pzi, PDBe:4pzi, PDBj:4pzi
PDBsum4pzi
PubMed29276034
UniProtQ9UMN6|KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Gene Name=KMT2B)

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