Structure of PDB 4py0 Chain A

Receptor sequence
>4py0A (length=389) Species: 562,9606 [Search protein sequence]
SLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLK
NTVISDLLMILTFPFKILSDAKTGPLRTFVCQVTSVIFYFTMYISISFLG
LITIDRYQKTTRPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNV
KKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVR
TADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLE
DKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRN
AYIQKYLRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRD
VFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSF
3D structure
PDB4py0 Agonist-bound structure of the human P2Y12 receptor
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AT A R93 C97 S101 Y105 S156 N159 K174 C175 K179 H187 V190 N191 C194 R256 Y259 Q263 K280 R77 C81 S85 Y89 S134 N137 K152 C153 K157 H165 V168 N169 C172 R340 Y343 Q347 K364
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007596 blood coagulation
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4py0, PDBe:4py0, PDBj:4py0
PDBsum4py0
PubMed24784220
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9H244|P2Y12_HUMAN P2Y purinoceptor 12 (Gene Name=P2RY12)

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