Structure of PDB 4pxz Chain A

Receptor sequence
>4pxzA (length=392) Species: 562,9606 [Search protein sequence]
SLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLK
NTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISF
LGLITIDRYQKTTRPPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRD
KNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRS
YVRTADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPP
KLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKT
TRNAYIQKYLRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ
TRDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSF
3D structure
PDB4pxz Agonist-bound structure of the human P2Y12 receptor
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AD A R93 C97 S101 V102 Y105 S156 N159 C175 K179 H187 V190 N191 C194 R256 Y259 Q263 K280 R79 C83 S87 V88 Y91 S137 N140 C156 K160 H168 V171 N172 C175 R343 Y346 Q350 K367
BS02 CLR A S55 N65 I68 W149 F153 S41 N51 I54 W130 F134
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007596 blood coagulation
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4pxz, PDBe:4pxz, PDBj:4pxz
PDBsum4pxz
PubMed24784220
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9H244|P2Y12_HUMAN P2Y purinoceptor 12 (Gene Name=P2RY12)

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