Structure of PDB 4pxi Chain A

Receptor sequence
>4pxiA (length=194) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
LRAEQTRATIIGAAADLFDRRGYESTTLSEIVAHAGVTKGALYFHFAAKE
DLAHAILEIQSRTSRRLAKDLDGRGYSSLEALMRLTFGMARLCVQGPVLR
AGLRLATAPVRPPLPHPFTEWREIATSRLLDAVRQSDVHQDIDVDSVAHT
LVCSVVGTREPRRLAEMWYILIRGMVPVTRRARYVTLAARLEQE
3D structure
PDB4pxi Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2)
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T42 G44 F48 T38 G40 F44 PDBbind-CN: Kd=200nM
BS02 dna A T31 L32 S33 Y47 A52 K53 T27 L28 S29 Y43 A48 K49 PDBbind-CN: Kd=200nM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4pxi, PDBe:4pxi, PDBj:4pxi
PDBsum4pxi
PubMed25092919
UniProtO66122

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