Structure of PDB 4pxa Chain A

Receptor sequence
>4pxaA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
DWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSD
VEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAF
LLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYE
EARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERG
KIGLDFCKYLVLDEADRMLVMGFEPQIRRIVEQDTMPPKGVRHTMMFSAT
FPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDL
LNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEAL
HQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGR
VGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAY
3D structure
PDB4pxa Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T156 I158 Y200 R202 T204 Q207 T226 G227 G229 K230 T22 I24 Y66 R68 T70 Q73 T92 G93 G95 K96
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4pxa, PDBe:4pxa, PDBj:4pxa
PDBsum4pxa
PubMed25724843
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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