Structure of PDB 4px9 Chain A

Receptor sequence
>4px9A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
DWSKPLPPSERLEQELFYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNI
ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSD
GPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRV
RPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLV
LDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARD
FLDEYIFLAVGR
3D structure
PDB4px9 Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A Y200 Q207 T226 G227 G229 K230 T231 Y55 Q62 T81 G82 G84 K85 T86
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4px9, PDBe:4px9, PDBj:4px9
PDBsum4px9
PubMed25724843
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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