Structure of PDB 4pw7 Chain A

Receptor sequence
>4pw7A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
IVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLV
LAGGFADEVDRGDEFTYTGSGGKKRIGAPSADQTLTNMNRALALNCDAPL
DDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWP
EISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYP
3D structure
PDB4pw7 Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
ChainA
Resolution2.001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F461 R462 V475 G476 G477 A492 G494 F495 Y507 T508 S510 G511 R520 I521 K569 F21 R22 V35 G36 G37 A52 G54 F55 Y67 T68 S70 G71 R75 I76 K124
BS02 dna A H474 H479 R481 S482 R520 H34 H39 R41 S42 R75
External links
PDB RCSB:4pw7, PDBe:4pw7, PDBj:4pw7
PDBsum4pw7
PubMed24813944
UniProtQ96PU4|UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (Gene Name=UHRF2)

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