Structure of PDB 4pvg Chain A

Receptor sequence
>4pvgA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
FETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVE
RGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNT
ERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSA
GIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQY
RFIYMAVQHYIETL
3D structure
PDB4pvg Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D425 C459 R465 T466 Q506
Catalytic site (residue number reindexed from 1) D164 C198 R204 T205 Q245
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2WT A C459 S460 R465 Q506 Q510 C198 S199 R204 Q245 Q249 BindingDB: IC50=14000nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4pvg, PDBe:4pvg, PDBj:4pvg
PDBsum4pvg
PubMed
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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