Structure of PDB 4pop Chain A

Receptor sequence
>4popA (length=177) Species: 416870 (Lactococcus cremoris subsp. cremoris MG1363) [Search protein sequence]
FNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTA
GLVGGLIWGILSMITGHAYILSLSQAFLEYLVAPVSLGIAGLFRQKTAPL
KLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAVNGISG
ILTAIAAFVILIIFVKKFPKLFIHSNY
3D structure
PDB4pop Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2VY A W34 E84 Y85 H125 W133 N151 W29 E79 Y80 H120 W128 N146 PDBbind-CN: -logKd/Ki=8.13,Kd=7.44nM
BindingDB: Kd=7.44nM
Gene Ontology
Molecular Function
GO:0015234 thiamine transmembrane transporter activity
Biological Process
GO:0015888 thiamine transport
GO:0071934 thiamine transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pop, PDBe:4pop, PDBj:4pop
PDBsum4pop
PubMed25676607
UniProtA2RI47|THIT_LACLM Thiamine transporter ThiT (Gene Name=thiT)

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