Structure of PDB 4poh Chain A

Receptor sequence
>4pohA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAP
3D structure
PDB4poh Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K284 L294 V298 R302 T449 F450 E453 A457 K40 L50 V54 R58 T205 F206 E209 A213
BS02 2VR A I268 A271 A272 Q275 W305 F313 R316 L326 L436 I24 A27 A28 Q31 W61 F69 R72 L82 L192 MOAD: Kd=10nM
PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
BindingDB: EC50=620nM,Kd=10.0nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4poh, PDBe:4poh, PDBj:4poh
PDBsum4poh
PubMed24801499
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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