Structure of PDB 4pnr Chain A

Receptor sequence
>4pnrA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTH
RRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYF
AENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS
AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
3D structure
PDB4pnr Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainA
Resolution1.71 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C120 H123 C128 C131
BS02 G18 A H1031 G1032 Y1050 Y1060 F1061 K1067 S1068 Y1071 H70 G71 Y89 Y99 F100 K106 S107 Y110 PDBbind-CN: -logKd/Ki=6.34,IC50=0.456uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4pnr, PDBe:4pnr, PDBj:4pnr
PDBsum4pnr
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]