Structure of PDB 4pmt Chain A

Receptor sequence
>4pmtA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLDKMLVAVKALDFQREAEL
LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG
GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLV
VKIGDFSRDIYSTDYYRVTMLPIRWMPPESILYRKFTTESDVWSFGVVLW
EIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREP
QQRHSIKDVHARLQALAQAHHHH
3D structure
PDB4pmt Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 A652 R654 N655 D668 S677 L689
Catalytic site (residue number reindexed from 1) D137 A139 R141 N142 D155 S162 L171
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 31Y A L516 G517 A542 F589 M592 R599 L657 R673 L16 G17 A38 F76 M79 R86 L144 R158 MOAD: ic50=997nM
PDBbind-CN: -logKd/Ki=6.00,IC50=997nM
BindingDB: IC50=997nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pmt, PDBe:4pmt, PDBj:4pmt
PDBsum4pmt
PubMed24914455
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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