Structure of PDB 4pmp Chain A

Receptor sequence
>4pmpA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLKMLVAVKALKSARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV
GQGLVVKIGDFGMSRIYSTDYYRVGTMLPIRWMPPESILYRKFTTESDVW
SFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMR
GCWQREPQQRHSIKDVHARLQALAQAHHHH
3D structure
PDB4pmp Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 A652 R654 N655 D668 S677 L689
Catalytic site (residue number reindexed from 1) D142 A144 R146 N147 D160 S168 L178
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 31W A A542 L564 V573 F589 E590 Y591 M592 L657 G667 D668 F669 A38 L56 V65 F81 E82 Y83 M84 L149 G159 D160 F161 MOAD: Kd~400nM
PDBbind-CN: -logKd/Ki=6.40,Kd~400nM
BindingDB: Kd=400nM,IC50=549nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4pmp, PDBe:4pmp, PDBj:4pmp
PDBsum4pmp
PubMed24914455
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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